abstract：BACKGROUND:Oral leukoplakia is a precancerous disorder that is common among residents in Linxian. However, the associations between oral leukoplakia and upper gastrointestinal cancers have not been reported. We investigated the relationships between oral leukoplakia and upper gastrointestinal cancers in the Linxian Gen...

journal_title：Oral oncology

authors： Fan JH,Wang JB,Qu CX,Zhang YQ,Taylor PR,Abnet CC,Dawsey SM,Qiao YL

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Head and neck cancer patients and their caregivers report high rates of psychological distress. High rates of physical symptom burden and the increased need for family members to provide caregiving during treatment may contribute to this distress. METHODS:This study examined trajectories of patient and care...

journal_title：Oral oncology

authors： Badr H,Gupta V,Sikora A,Posner M

更新日期：2014-10-01 00:00:00

abstract：:The stage IVC nasopharyngeal carcinoma is a catch-all entity covering minute solitary metastasis to bulky disseminated disease. Prognosis varies greatly within this stage group. A subset of patients with oligometastases may benefit from aggressive local ablative therapy. Meanwhile, in multiple metastatic diseases, cus...

journal_title：Oral oncology

authors： Chan OS,Ngan RK

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Loss of Von Hippel-Lindau (VHL) gene expression has been implicated in the development of human cancers. However, its function in oral squamous cell carcinoma (OSCC) remains undefined. The aim of this study was to clarify the VHL expression in OSCC and to explore the underlying mechanisms of VHL in modulating...

journal_title：Oral oncology

authors： Zhang S,Zhou X,Wang B,Zhang K,Liu S,Yue K,Zhang L,Wang X

更新日期：2014-09-01 00:00:00

abstract：:Histological assessment is an essential tool in the diagnosis and guidance of the treatment of various diseases, in particular cancer, of the head and neck. Recent major advances in optical imaging techniques have made it possible to acquire high-resolution in vivo images at the cellular scale. Confocal endomicroscopy...

journal_title：Oral oncology

authors： Abbaci M,Breuskin I,Casiraghi O,De Leeuw F,Ferchiou M,Temam S,Laplace-Builhé C

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:A standardized assay to determine the HPV status of head and neck squamous cell carcinoma (HNSCC) specimens has not yet been established, particularly for cytologic samples. The goal of this study was to determine whether the hybrid capture-2 (HC-2) assay, already widely used for the detection of high risk HP...

journal_title：Oral oncology

authors： Smith DF,Maleki Z,Coughlan D,Gooi Z,Akpeng B,Ogawa T,Bishop JA,Frick KD,Agrawal N,Gourin CG,Ha PK,Koch WM,Richmon JD,Westra WH,Pai SI

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:The treatment strategy of early stage oral squamous cell carcinoma's (OSCC) resected with close or involved margins is a returning point of discussion. In this study we reviewed the consequences of re-resection (RR), postoperative radiotherapy (PORT) or watchful waiting (WW). PATIENTS AND METHODS:Two-hundre...

journal_title：Oral oncology

authors： Dik EA,Willems SM,Ipenburg NA,Adriaansens SO,Rosenberg AJ,van Es RJ

更新日期：2014-06-01 00:00:00

abstract：:Parapharyngeal space tumours are rare and most clinicians will only see a small number during their career. We performed a systematic review of 1143 parapharyngeal space tumors published in the past 20 years to increase cumulative experience. A systematic literature review was performed and data on histological diagno...

journal_title：Oral oncology

authors： Riffat F,Dwivedi RC,Palme C,Fish B,Jani P

更新日期：2014-05-01 00:00:00

abstract：:Nasopharyngeal carcinoma is well known to be a viral driven malignancy. Despite high loco-regional control rate with modern radiotherapy, distant metastasis remains as a major threat to the patients highlighting the importance of effective systemic therapy. Recent advances in the understanding of tumor biology, host c...

journal_title：Oral oncology

authors： Chiang AK,Mak NK,Ng WT

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Though the effect of age has been studied in some cancer types, its prognostic significance in oropharyngeal squamous cell carcinoma (OPSCC) remains controversial. Our purpose is to determine the impact of age at diagnosis on overall survival (OS) and disease-specific survival (DSS) in patients with OPSCC. I...

journal_title：Oral oncology

authors： Ryan Camilon P,Stokes WA,Nguyen SA,Lentsch EJ

更新日期：2014-05-01 00:00:00

abstract：:Oral cancer is a multifactorial disease in which both environmental and genetic factors contribute to the aetiopathogenesis. Oral cancer is the sixth most common cancer worldwide with a higher incidence among Melanesian and South Asian countries. More than 90% of oral cancers are oral squamous cell carcinoma (OSCC). T...

journal_title：Oral oncology

authors： Salahshourifar I,Vincent-Chong VK,Kallarakkal TG,Zain RB

更新日期：2014-05-01 00:00:00

abstract：:Health-related quality of life (HRQoL) is a subjective measure of patients' experience of disease and treatment. We systematically reviewed the literature to identify high quality manuscripts reporting HRQoL outcomes in adults with squamous cell carcinoma of the head and neck (HNSCC) treated with an organ-sparing cura...

journal_title：Oral oncology

authors： Klein J,Livergant J,Ringash J

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:The hepatocyte growth factor receptor (Met) is frequently overexpressed in Head and Neck Squamous Cell Carcinoma (HNSCC), correlating positively with high-grade tumors and shortened patient survival. As such, Met may represent an important therapeutic target. The purpose of this study was to explore the role...

journal_title：Oral oncology

authors： Tao X,Hill KS,Gaziova I,Sastry SK,Qui S,Szaniszlo P,Fennewald S,Resto VA,Elferink LA

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Pioglitazone has shown an inhibitory effect on the growth of cell lines derived from human salivary gland and human oral squamous cell carcinoma. However, whether this effect can be applied to patients with type 2 diabetes mellitus who use pioglitazone for glycemic control remains unanswered. METHODS:The re...

journal_title：Oral oncology

authors： Tseng CH

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:Induction chemotherapy (IC) followed by chemoradiation (CRT) for locally advanced squamous cell head and neck cancer (SCCHN) remains controversial in the absence of clear evidence to define its role. As part of a prospective, randomised, multicentre study of CRT for stage III/IV laryngeal/hypopharyngeal canc...

journal_title：Oral oncology

authors： Gujral DM,Piercy D,Morden JP,Emson M,Hall E,Miah AB,Bhide SA,Newbold KL,Harrington KJ,Nutting CM

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:Adenoid cystic carcinoma (ACC) is one of the most common malignancies of salivary glands, characterized by poor prognosis, particularly due to pulmonary metastasis. We previously reported that transforming growth factor (TGF)-β1 promoted ACC cell migration and invasion via the Smad pathway in vitro. The aim ...

journal_title：Oral oncology

authors： Dong L,Ge XY,Wang YX,Yang LQ,Li SL,Yu GY,Gao Y,Fu J

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:The need to improve chemotherapeutic efficacy against head and neck squamous cell carcinomas (HNSCC) is well recognized. In this study, we investigated the potential of targeting the established tumor vasculature in combination with chemotherapy in head and neck cancer. METHODS:Experimental studies were carrie...

journal_title：Oral oncology

authors： Folaron M,Kalmuk J,Lockwood J,Frangou C,Vokes J,Turowski SG,Merzianu M,Rigual NR,Sullivan-Nasca M,Kuriakose MA,Hicks WL Jr,Singh AK,Seshadri M

更新日期：2013-09-01 00:00:00

abstract：:Emerging evidence suggests the existence of a tumorigenic population of cancer cells that demonstrate stem cell-like properties such as self-renewal and multipotency. These cells, termed cancer stem cells (CSC), are able to both initiate and maintain tumor formation and progression. Studies have shown that CSC are res...

journal_title：Oral oncology

authors： Adams A,Warner K,Nör JE

更新日期：2013-09-01 00:00:00

abstract：:Thyroid cancer metastasizes to regional lymph nodes early and often. The impact of these metastases on outcome depends on the histological subtype and the size, number and location of those metastases, as well as patient's age. Whilst clinically apparent lateral nodal metastases have a significant impact on both survi...

journal_title：Oral oncology

authors： Nixon IJ,Shaha AR

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...

journal_title：Oral oncology

authors： de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM

更新日期：2013-06-01 00:00:00

abstract：:Pemetrexed has been evaluated as a novel chemotherapeutic for head and neck cancer (HNC). In this review, we examined the efficacy and tolerability of pemetrexed in patients with HNC. Relevant English-language literature was identified via PubMed and a review of published abstracts from the American Society of Clinica...

journal_title：Oral oncology

authors： Argiris A,Pennella E,Koustenis A,Hossain AM,Obasaju CK

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:Chemoradiation is the treatment of choice for carcinomas of the pharynx and larynx with imminent loss of organ or function. However, the prognosis after CRT decreases when salvage surgery becomes necessary. Single-cycle induction chemotherapy is therefore performed to identify patients who would benefit more...

journal_title：Oral oncology

authors： Semrau S,Schmidt D,Lell M,Waldfahrer F,Lettmaier S,Kuwert T,Iro H,Fietkau R

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Serologic analyses for anti-EBV antibodies used alone usually have low sensitivity for the diagnosis of nasopharyngeal carcinoma (NPC). We assumed that a combined determination of antibodies directed at EBV proteins expressed in both lytic and latent cycles could increase the sensitivity. MATERIALS AND METH...

journal_title：Oral oncology

authors： Ai P,Wang T,Zhang H,Wang Y,Song C,Zhang L,Li Z,Hu H

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT); gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically a...

journal_title：Oral oncology

authors： Studer G,Glanzmann C

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:Intact cell peptidome profiling (ICPP) with MALDI-ToF Mass Spectrometry holds promise as a non-invasive method to detect head and neck squamous cell carcinoma (HNSCC) objectively, which may significantly improve the early diagnosis of oral cancer. The present study was designed to discriminate between tumour...

journal_title：Oral oncology

authors： Maurer K,Eschrich K,Schellenberger W,Bertolini J,Rupf S,Remmerbach TW

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:Overexpression of the epidermal growth factor (EGF) receptor (EGFR) gene in the squamous cell carcinomas of the head and neck (SCCHN) is often associated with inauspicious prognosis and poor survival. N-acetylcysteine (NAC), a compound from some vegetables and allium species, appears anti-tumorigenesis, but ...

journal_title：Oral oncology

authors： Lee MF,Chan CY,Hung HC,Chou IT,Yee AS,Huang CY

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC). METHODS:OPC treated with RT/CRT from 1/1/2000 to 5/31/2010 were reviewed. The natural course of DM were compared between HPV(+) and HPV(-) cohorts. RESU...

journal_title：Oral oncology

authors： Huang SH,Perez-Ordonez B,Weinreb I,Hope A,Massey C,Waldron JN,Kim J,Bayley AJ,Cummings B,Cho BC,Ringash J,Dawson LA,Siu LL,Chen E,Irish J,Gullane P,Hui A,Liu FF,Shen X,Xu W,O'Sullivan B

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Angiotensin I-converting enzyme (ACE), a type I cell surface zinc metallopeptidase, is differentially expressed in several malignancies and plays a role in tumor cell proliferation, tumor cell migration, angiogenesis, and metastatic behavior. We aimed to investigate the effects of ACE gene (rs1799752) varian...

journal_title：Oral oncology

authors： Liu YT,Lin LW,Chen CY,Wang CP,Liu HP,Houng JY,Chung FM,Shieh TY

更新日期：2012-12-01 00:00:00

abstract：:Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to c...

journal_title：Oral oncology

authors： Zhou C,Liu J,Tang Y,Liang X

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Platinum-based chemotherapy is the recognized first-line treatment for metastatic nasopharyngeal carcinoma (NPC). However there is no standard second-line treatment. This study was designed to evaluate the efficacy and safety of a gemcitabine and vinorelbine combination (GV) in patients with metastatic NPC p...

journal_title：Oral oncology

authors： Chen C,Wang FH,Wang ZQ,An X,Luo HY,Zhang L,Chen YC,Xu RH,Li YH

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Hypothesizing that neck-level specific locations of residual lymph node metastases following chemoradiation for head and neck cancer are highly predictable, the efficacy of the more targeted lymphadenectomy procedure called super-selective neck dissection (SSND) was evaluated. METHODS:A retrospective analys...

journal_title：Oral oncology

authors： Robbins KT,Dhiwakar M,Vieira F,Rao K,Malone J

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Surgical management of patients following zoledronic acid therapy is particularly difficult, since the dental extraction is the main cause of BRONJ. METHODS:A case-control study was conducted on 176 patients treated with intravenous (IV) bisphosphonates for oncologic pathologies who also underwent dental ex...

journal_title：Oral oncology

authors： Mozzati M,Arata V,Gallesio G

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:To report oncologic outcomes of patients with paranasal sinus cancer (PNSC) treated by surgery and radiotherapy or (chemo)radiation and to investigate the impact of improving the radiation technique on outcomes and toxicity. MATERIALS AND METHODS:Between 1999 and 2010, 82 consecutive patients with PNSC were...

journal_title：Oral oncology

authors： Al-Mamgani A,Monserez D,Rooij Pv,Verduijn GM,Hardillo JA,Levendag PC

更新日期：2012-09-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) plays a significant role in cancer therapy as receptors of bacteria-derived immunotherapeutic agents such as OK-432, a streptococcal immunotherapeutic agent. In addition, recent reports demonstrated that TLRs, including TLR4, are also expressed in cancer cells as well as in immunocompetent ...

journal_title：Oral oncology

authors： Tano T,Okamoto M,Kan S,Nakashiro K,Shimodaira S,Yamashita N,Kawakami Y,Hamakawa H

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS:From January 2005 to September 2008, medical records of 131 consecutive patients with oral...

journal_title：Oral oncology

authors： Chen PY,Chen HH,Hsiao JR,Yang MW,Hsueh WT,Tasi ST,Lin FC,Wu YH

更新日期：2012-08-01 00:00:00

abstract：:Hepatoma-derived growth factor (HDGF) participates in oncogenic progression and represents a prognostic factor in several types of cancer. This study aimed to elucidate the role of HDGF during oral carcinogenesis. HDGF expression and the tumorigenic behaviors in human oral cell lines were investigated by immunoblottin...

journal_title：Oral oncology

authors： Lin YW,Li CF,Chen HY,Yen CY,Lin LC,Huang CC,Huang HY,Wu PC,Chen CH,Chen SC,Tai MH

更新日期：2012-07-01 00:00:00

abstract：:In loco-regionally advanced head and neck squamous cell cancer (HNSCC), concurrent 3-weekly cisplatin improves overall survival (OS) compared to radiotherapy alone, but is often associated with renal toxicity. The use of radiotherapy with accelerated fractionation schedules has been reported to improve survival but it...

journal_title：Oral oncology

authors： Espeli V,Zucca E,Ghielmini M,Giannini O,Salatino A,Martucci F,Richetti A

更新日期：2012-03-01 00:00:00

abstract：:Large cell neuroendocrine carcinoma is a poorly differentiated neuroendocrine carcinoma that usually occurs in the lung. Although rare in the head and neck, salivary and mucosal subtypes are recognized. This article describes their characteristic light microscopic and immunohistochemical features and highlights the im...

journal_title：Oral oncology

authors： Kusafuka K,Ferlito A,Lewis JS Jr,Woolgar JA,Rinaldo A,Slootweg PJ,Gnepp DR,Devaney KO,Travis WD,Barnes L

更新日期：2012-03-01 00:00:00

abstract：:The development of locoregional recurrence is the main reason for treatment failure in head and neck squamous cell carcinomas (HNSCC) and the remaining of tumor cells in surgical margins is associated with recurrence. Surgical margins are considered negative based on histologic assessment of the pathological specimen....

journal_title：Oral oncology

authors： de Carvalho AC,Kowalski LP,Campos AH,Soares FA,Carvalho AL,Vettore AL

更新日期：2012-03-01 00:00:00

abstract：:To describe outcome and prognostic factors in a national Danish series of patients treated for salivary gland carcinoma. From three Danish nation-wide registries and supplementary patient records, 871 patients diagnosed with primary major or minor salivary gland carcinoma in the period from 1990 to 2005 were identifie...

journal_title：Oral oncology

authors： Bjørndal K,Krogdahl A,Therkildsen MH,Overgaard J,Johansen J,Kristensen CA,Homøe P,Sørensen CH,Andersen E,Bundgaard T,Primdahl H,Lambertsen K,Andersen LJ,Godballe C

更新日期：2012-02-01 00:00:00